IMAGINATION AND KNOWLEDGE CREATE TOMORROW'S INNOVATIONS
Welcome to Kherion® Technology Limited, a biotech company looking beyond convention.
Kherion Technology is a privately held biotechnology company headquartered in Cambridge, U.K., working on the immunomodulatory treatment of chronic autoimmune and inflammatory disease.
The company's lead programme, KHER-001, is in preclinical development and is protected by a granted U.S. method-of-use patent. A longer-term interest in oncology is described under Science.
KHER-001: Kherion's lead programme is in preclinical development for chronic autoimmune and inflammatory disease. It is protected by a granted U.S. method-of-use patent covering the treatment of autoimmune disease, including Crohn's disease, inflammatory bowel disease and sarcoidosis, with a defined composition at a concentration effective to reduce chronic inflammation while promoting an immune response.
Chronic autoimmune diseases: Current treatments, typically, rely on immune suppression and can be dangerous due to serious side-effects, such as life-threatening infections. In addition, immunosuppression is mostly limited to alleviating signs and symptoms but is largely ineffective in treating chronic autoimmune diseases.
Cancer: Oncology is a planned second programme for Kherion rather than a current one. Many new treatments operate on the basis of immune cell gene manipulation, such as chimeric antigen receptor T (CAR-T) cell therapy, which comes with its own set of issues to overcome. Today, cancer is seen more as a disease of molecular mechanisms caused by specific gene mutations than a disease of specific organs. Thus, for example, treatment for colorectal cancer may turn out to be useful in treating breast cancer.
Proprietary compounds of Kherion® Technology ‘work with’, rather than inhibit or block, the immune system to treat chronic autoimmune diseases and cancer.
Kherion Technology drug candidates:
Dr Mixon founded Kherion Technology and leads the KHER-001 programme, with responsibility for the company's scientific and regulatory strategy.
He trained in microbiology at Emory University, Atlanta; in pathology at Grady Memorial Hospital, Atlanta; and worked in the Rabies Unit at the Institut Pasteur, Paris. He received his Ph.D. in Molecular Virology from the University of Cambridge.
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Professor Sir Alan Fersht FRS FMedSci is a leading authority in protein engineering and protein folding. He read Natural Sciences at Gonville and Caius College, Cambridge, and took his Ph.D. there in 1968, after which he spent a postdoctoral year at Brandeis University with William Jencks. He returned to Cambridge in 1969 as a Group Leader at the MRC Laboratory of Molecular Biology, where he shared a laboratory with Max Perutz.
In 1977 he was appointed to succeed Dorothy Hodgkin as Wolfson Research Professor of the Royal Society, and from 1978 to 1988 he held that chair together with the Professorship of Biological Chemistry at Imperial College London, spending a sabbatical year at Stanford University with Arthur Kornberg on an Eleanor Roosevelt Fellowship of the American Cancer Society. From 1981 he began the long collaboration with Greg Winter that developed protein engineering as a method for dissecting protein structure, stability and function. In 1988 he was invited back to Cambridge as Herchel Smith Professor of Organic Chemistry, a chair he held until 2010, and he directed the Centre for Protein Engineering from 1990 to 2010. He was Master of Gonville and Caius College from 2012 to 2018 and is a Life Fellow of the College.
Sir Alan was elected a Fellow of the Royal Society in 1983 and knighted in 2003. He is a Foreign Associate of the US National Academy of Sciences, a Member of the American Academy of Arts and Sciences, of the American Philosophical Society and of the Accademia Nazionale dei Lincei, a member of EMBO and a Fellow of the Academy of Medical Sciences. The Royal Society has awarded him its Gabor Medal in 1991, Davy Medal in 1998, Royal Medal in 2008 and Copley Medal in 2020. Now emeritus at the Laboratory of Molecular Biology, where his laboratory worked for many years on the tumour suppressor p53, he maintains his research interests in protein folding and misfolding.
Professor Timothy Cox is Professor of Medicine Emeritus at the University of Cambridge, a Life Fellow of Sidney Sussex College and an Honorary Consultant Physician at Addenbrooke's Hospital, U.K.
After qualifying at the London Hospital Medical College and clinical training in Oxford and at the Royal Postgraduate Medical School, Hammersmith, London, he was a visiting scientist at the Massachusetts Institute of Technology and at the Sir William Dunn School in Oxford. He held consultant posts in internal medicine, gastroenterology and haematology, and his clinical interest throughout has been in the inherited metabolic diseases. He helped establish the network of specialist treatment centres for those diseases in England, which grew out of the first four such centres, created in 1997.
He led his own laboratories from 1979 until 2020 and now conducts computational and analytical research. He was the founding Director of the Cambridge MB/PhD Programme, which he initiated and led from 1989 to 2014 and which was the first integrated programme of its kind in the United Kingdom and Europe, and he has personally supervised seventeen doctoral students. He has published more than 260 original articles and is an editor of the three-volume Oxford Textbook of Medicine, whose sixth edition was published by Oxford University Press in 2020.
Mr James Thomas Mixon holds an MBA in Corporate Finance from the Wharton School, University of Pennsylvania. Before retiring he spent some thirty years at the IBM Corporation. As a financial analyst he coordinated the preparation, consolidation and presentation of divisional annual operating budgets and strategic financial plans, and reported routine and period-end results against forecast and budget across profit and loss, manpower and capital expenditure. His experience also covers computer operating systems development and systems engineering.
While on faculty loan from IBM to Hampton University, Virginia, he taught the theory and practice of managerial finance, computer coding and general accounting.
Kherion Technology seeks “snake killers” who can read the ingredients on a chewing gum wrapper and unlock the secrets of the Universe.
Intrigued? Read on:
“I come from an environment where, if you see a snake, you kill it. At GM, if you see a snake, the first thing you do is go hire a consultant on snakes. Then you get a committee on snakes, and then you discuss it for a couple of years. The most likely course of action is -- nothing. You figure, the snake hasn't bitten anybody yet, so you just let [it] crawl around on the factory floor. We need to build an environment where the first [person] who sees the snake kills it.” – Thomas Moore, “The GM System Is Like A Blanket of Fog”, Fortune, February 15, 1988.
“Some people can read War and Peace and come away thinking it's a simple adventure story. Others can read the ingredients on a chewing gum wrapper and unlock the secrets of the Universe.” (Superman, 1978).
Sounds like you? Apply when positions become available, below.
Kherion Technology Limited
St John's Innovation Centre Ltd
Cowley Road
Cambridge
CB4 0WS
England
United Kingdom
Email: info{at}kherion-technology{dot}com